Finetunes distribution1/4/2024 Trafficking of cellular components in a coordinated manner represents a major challenge for all cells. Altogether, this work implicates LAMP5 function in GABAergic neurotransmission in defined neuronal subpopulations. At the behavioral level, LAMP5 mutant mice showed decreased anxiety and deficits in olfactory discrimination. Electrophysiological analyses in mutants showed alterations in short term synaptic plasticity suggesting that LAMP5 is involved in controlling the dynamics of evoked GABAergic transmission. ![]() In LAMP5-deficient mice localization of the transporter was unaffected arguing against a conserved role in VGAT trafficking. The protein was present at synaptic terminals, overlapping with the mammalian vesicular GABA-transporter VGAT. We show here that in the mouse brain LAMP5 is expressed in subpopulations of GABAergic forebrain neurons in the striato-nigral system and the olfactory bulb. elegans, the LAMP5 ortholog UNC-46 has been suggested to act a trafficking chaperone, essential for the correct targeting of the nematode vesicular GABA-transporter UNC-47. In contrast to the canonical members of this protein family, LAMP1 and LAMP2, which show widespread expression in many tissues, LAMP 5 is brain specific in mice. ![]() Tyton Partners served as the exclusive financial adviser to Finetune.LAMP5 is member of the LAMP family of membrane proteins. For more information, please visit Finetune - Creating AI-Human hybrid solutions for learning (). For more information, visit Prometric or follow us on Twitter at About Finetuneįinetune is a leading innovator in the education sector, specializing in the development of hybrid AI-human-solutions that address some of the most challenging problems including automated content generation and AI-powered learning-resource classification. Today, we are paving the industry's path forward with new solutions and innovation to ensure reliable access to secure assessments anytime, anywhere. Our integrated, end-to-end solutions provide exam development, management, and distribution that set the industry standard in quality, security, and service excellence. Prometric is a leading provider of technology-enabled testing and assessment solutions. Joining Prometric allows us to further build on our success, taking these solutions to market at scale and continuing to invest in emerging technologies that serve the wide cross section of markets we serve." Steve Shapiro, CEO of Finetune, said, "We are energized by the synergy that a partnership with Prometric represents. I am excited by the opportunity that these advanced capabilities represent for the way we support our customers and test takers." Roy Simrell, President and CEO of Prometric LLC, said, "The addition of Finetune to Prometric's portfolio represents a significant opportunity to not only bring cutting-edge AI content and assessment technology to our suite of solutions but to transform the way organizations address the challenges they face in a rapidly changing learning landscape. Finetune's flagship products, Generate™ and Catalog™, are the world's first commercially available products to use state-of-the-art Natural Language Processing (NLP) transformer models to power AI-driven content generation and classification, increasing the productivity and creativity of item-authoring and classification, in tandem with subject matter experts, while greatly improving quality. They expanded in recent years into proprietary AI-assisted technology targeting the growing demand among organizations and companies for the ability to create high-quality assessment and other learning content with greater time- and cost-efficiency than traditional approaches. ![]() ![]() Finetune, based in Boston with a pre-pandemic globally distributed team, has been developing innovative solutions in learning, instruction, and assessment for more than a decade.
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